Effective school and district leaders implement instructional strategies that align with and build on learning and human development research to ensure that teaching practices, tools, and resources address the human brain, cognition, memory, information processing, and learning. While research on effective instructional strategies is extensive (see, for example, Visible Learning, The New Art and Science of Teaching, High-Impact Instruction, and Enhancing Professional Practice: A Framework for Teaching), findings are continually evolving and should be accessed routinely to inform educational decisions, programs, and practice. School leaders must assign priority to understanding the new findings to advance instructional practices that optimize how the brain learns and develops. Recognizing that learning and human development research has significant implications for pre-K–12 education, effective education leaders emphasize the importance of designing brain-compatible and developmentally appropriate learning experiences, so that students’ opportunities to master future-ready skills are optimized. School and district leaders who become proficient in the implications of learning and human development research position themselves to effectively lead the implementation of evidence-based practices to consistently yield high-level results.